A Frank Statement to Cigarette Smokers was a historic advertisement run by major American tobacco companies on January 4, 1954 in response to a study showing that cigarette tar caused cancerous tumors on mouse skin.[1] The ad ran in more than 400 newspapers throughout the U.S. aimed at an estimated 43 million people.[2] The ad was the first in a campaign to dispute reports that smoking cigarettes could cause lung cancer and had other dangerous health effects.[1]